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Symbol
Name
ID

Tmem106b
transmembrane protein 106B
MGI:1919150

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Delayed CNS myelination

Leukodystrophy

Hypoplasia of the corpus callosum

Dysmetria

Gait ataxia

Choreoathetosis

Intention tremor

Abnormal pyramidal sign

Absent speech

Delayed speech and language development

Dysarthria

Psychosis

Intellectual disability

Hyperreflexia

Brisk reflexes

Dystonia

Broad-based gait

Shuffling gait

Stooped posture

Global developmental delay

Delayed ability to walk

Seizure

Disease(s) Associated with TMEM106B

hypomyelinating leukodystrophy 16

Mouse Phenotypes		nervous system phenotype	decreased brain weight	abnormal motor neuron morphology	abnormal axon morphology	abnormal axon initial segment morphology	abnormal neuromuscular synapse morphology	spongiform encephalopathy
Availability	Mouse Genotype	nervous system phenotype	decreased brain weight	abnormal motor neuron morphology	abnormal axon morphology	abnormal axon initial segment morphology	abnormal neuromuscular synapse morphology	spongiform encephalopathy
	Tmem106b^em1Damme/Tmem106b^em1Damme	*
	Tmem106b^{tm2b(KOMP)Wtsi}/Tmem106b^{tm2b(KOMP)Wtsi}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23